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Search Results for " purine nucleoside phosphorylase "

14

抑制剂 & 化合物

2

天然产物

1

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T76096	Purine nucleoside phosphorylase
	Purine nucleoside phosphorylase 是嘌呤代谢中的关键酶，参与嘌呤挽救途径。Purine nucleoside phosphorylase 缺乏导致 T 细胞功能受损。在无机正磷酸盐作为第二底物的存在下，Purine nucleoside phosphorylase 催化核糖和脱氧核糖核苷的糖苷键断裂，生成嘌呤碱和核糖（脱氧核糖）-1-磷酸。
T9727	2'-Fluoro-2'-Deoxyadenosine	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	2′-Deoxy-2′-fluoroadenosine 可用于合成2 ' -脱氧-2 ' -氟修饰的寡核苷酸。它能被大肠杆菌嘌呤核苷磷酸化酶（PNP）有效地分解成毒性物 2-氟腺嘌呤，对表达大肠杆菌 PNP 的肿瘤表现出良好的体内活性。
T7782	3'-Deoxyguanosine	Others	Others
	3'-Deoxyguanosine 是一种配体，可与酶如嘌呤核苷磷酸化酶和受体复合。
T67822L	Ulodesine BCX4208	Endogenous Metabolite	Metabolism
	Ulodesine (BCX4208) 是一种嘌呤核苷磷酸化酶 (PNP) 抑制剂，对 PNP 有抑制作用，IC50 值为 2.293 nM/L。Ulodesine 可用于研究高尿酸血症。
T12399	Peldesine BCX 34	Nucleoside Antimetabolite/Analog; HIV Protease	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Peldesine (BCX 34) 是一种有效的、竞争性的、可逆的和口服活性的嘌呤核苷磷酸化酶抑制剂。 Peldesine 抑制 T 细胞增殖，IC50 为 800 nM。 Peldesine 可用于皮肤 T 细胞淋巴瘤、牛皮癣和 HIV 感染的研究。
T14964	CI 972 anhydrous CI 972 (anhydrous)	Others	Others
	CI 972 anhydrous is an inhibitor of purine nucleoside phosphorylase (PNP) (Ki: 0.83 μM) used as a T cell-selective immunosuppressive agent.
T70768	MDL-74428
	MDL-74428 is an inhibitor of purine nucleoside phosphorylase.
T70939	8-Aminoinosine
	8-Aminoinosine is an endogenous 8-aminopurine that induces diuresis, natriuresis, and glucosuria by inhibiting purine nucleoside phosphorylase (PNPase).
TNU1023	7-Deaza-2’-deoxyadenosine
	Nucleoside Derivatives –7-Deaza-purine nucleosides; Drugs and Inhibitors; Purine nucleoside phosphorylase inhibitor
T19148	5-Aza-7-deazaguanine	Others	Others
	5-Aza-7-deazaguanine is a substrate for E. coli purine nucleoside phosphorylase (wild-type/Ser90Ala mutant) in the synthesis of base-modified nucleosides.
T78379	9-Deazaguanine	Others	Others
	9-Deazaguanine，一种核苷类似物，有效抑制嘌呤核苷磷酸化酶（PNP）。
T15337	Forodesine 呋咯地辛,BCX-1777,Immucillin-H	Others	Others
	Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine is an orally active inhibitor of purine nucleoside phosphorylase (IC50s: 0.48 to 1.57 nM for human, mouse, rat, monkey, and dog PNP). It could induce apoptosis in leukemic cells b
T11313	Forodesine hydrochloride BCX-1777 hydrochloride,Immucillin-H hydrochloride	Others	Others
	Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP.
T60799	Peldesine dihydrochloride
	Peldesine (BCX 34) dihydrochloride 是一种有效的，竞争性，可逆和口服活性的嘌呤核苷磷酸化酶 (PNP) 抑制剂，对人，大鼠和小鼠红细胞 (RBC)PNP 的 IC50分别为 36 nM，5 nM 和 32 nM。Peldesine dihydrochloride 还是一种 T 细胞 (T-cell) 增殖抑制剂，IC50为 800 nM。Peldesine dihydrochloride 可用于皮肤 T 细胞淋巴瘤，牛皮癣和 HIV 感染的研究。

化合物

Purine nucleoside phosphorylase

Cat.No: T76096

2'-Fluoro-2'-Deoxyadenosine

Cat.No: T9727

Target: Nucleoside Antimetabolite/Analog

3'-Deoxyguanosine

Cat.No: T7782

Target: Others

Cat.No: T67822L

Synonym: BCX4208

Target: Endogenous Metabolite

Cat.No: T12399

Synonym: BCX 34

Target: Nucleoside Antimetabolite/Analog, HIV Protease

CI 972 anhydrous

Cat.No: T14964

Synonym: CI 972 (anhydrous)

Target: Others

Cat.No: T70768

Cat.No: T70939

7-Deaza-2’-deoxyadenosine

Cat.No: TNU1023

5-Aza-7-deazaguanine

Cat.No: T19148

Target: Others

Cat.No: T78379

Target: Others

Cat.No: T15337

Synonym: 呋咯地辛,BCX-1777,Immucillin-H

Target: Others

Forodesine hydrochloride

Cat.No: T11313

Synonym: BCX-1777 hydrochloride,Immucillin-H hydrochloride

Target: Others

Peldesine dihydrochloride

Cat.No: T60799

Cat. No.	Product Name	Target	Signaling Pathways
T1709	2'-Deoxyinosine Guanine deoxyriboside,Deoxyinosine,2'-脱氧肌苷	Others; Endogenous Metabolite	Metabolism; Others
	2'-Deoxyinosine (Guanine deoxyriboside) 具有抑制人癌细胞株生长的活性，并发现其与嘌呤核苷磷酸化酶缺乏有关。
T13539	Allopurinol riboside	Others; Endogenous Metabolite; Parasite; Drug Metabolite	Metabolism; Microbiology/Virology; Others
	Allopurinol riboside 是别嘌醇的代谢产物，具有抗寄生虫作用。 Allopurinol riboside 竞争性抑制嘌呤核苷磷酸化酶对肌苷的作用，Ki 为 277 μM。

天然产物

2'-Deoxyinosine

Cat.No: T1709

Synonym: Guanine deoxyriboside,Deoxyinosine,2'-脱氧肌苷

Target: Others, Endogenous Metabolite

Allopurinol riboside

Cat.No: T13539

Target: Others, Endogenous Metabolite, Parasite, Drug Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02279	Nucleoside phosphorylase/PNP Protein, Human, Recombinant (His) PUNP,PRO1837,purine nucleoside phospho...	Human	E. coli
	Purine nucleoside phosphorylase (PNP) is a purine-metabolizing enzyme that catalyzes the reversible phosphorolysis of 6-oxypurine (deoxy)nucleosides to their respective bases and (deoxy)ribose-1-phosphate. It is a key enzyme in the purine salvage pathway of mammalian cells. Purine nucleoside phosphorylase is a transferase that catalyzes the addition of phosphate and removal of a purine base from guanosine and similar nucleosides.PNP defects result in metabolic abnormalities and fatal T cell immu...

重组蛋白

Nucleoside phosphorylase/PNP Protein, Human, Recombinant (His)

Cat.No: TMPY-02279

Species: Human

Expression System: E. coli

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